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Sitagliptin Phosphate Monohydrate
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Description and usage
Sitagliptin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is not used to treat type 1 diabetes or patients with a history of pancreatitis. It is also used in combination with metformin 8 or ertugliflozin.
Structure
General Data
Chemical Name: 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R )-3-amino-1-oxo-4-(2,4,5-trifluoro
-phenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1) monohydrate;
7-[(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine monophosphate monohydrate;
(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate.
Sitagliptin Phosphate Monohydrate
Cas no.: 654671-77-9
Molecular formula: C16H15F6N5O.H3PO4.H2O
Molecular weight: 523.32 g/mol
Reference
BP2020 & USP43